Tyvaso DPI

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TYVASO and TYVASO DPI are approved for the treatment of pulmonary arterial hypertension (PAH; WHO Group 1) and pulmonary hypertension associated with interstitial lung disease (PH-ILD;  WHO Group 3) to improve the ability to exercise. 

TYVASO DPI received high satisfaction marks from 45 of 46 people in a clinical study who switched from the TYVASO nebulizer. 98% Patient Satisfaction with TYVASO DPI.

It can be used for the same indications as the nebulized form.

Use of Device

Taking a dose is as simple as:



Available in a variety of cartridge strengths, which are color-coded to help you know which ones to take. Each dose is inhaled in less than 2 seconds bubbles.


Your medicine will be shipped directly to you in a kit that contains all that you need to start and continue with TYVASO DPI. Each kit is conveniently packed with a 4-week supply of disposable inhalers and cartridges.

Tyvaso Side Effects
  Side Effect Severity Mild Moderate Severe
Likely (>10%) Cough (54%)
Headache (41%)
Throat Irritation / Pharyngolaryngeal Pain
Flushing (15%)
Nausea (19%)
Less Likely (1-10%) Peripheral edema (5%) Syncope (6%)
Rare (<1%)

The following potential approaches to managing the most common side effects with Tyvaso are based on anecdotal evidence and should not be construed as medical advice. United Therapeutics does not recommend or endorse using healthcare products other than as directed or prescribed.

Talk with your doctor or nurse about the things you can do to help manage side effects, such as, if you develop a cough or throat irritation.

Before Treatment:

  • Try an over-the-counter cough medicine to help reduce cough
  • Use a throat spray to numb your throat
  • Try drinking cold or hot water

During Treatment:

  • Avoid holding your breath once you inhale

After Treatment:

  • Rinse mouth with water (do not swallow the water)

Your doctor may also recommend taking fewer breaths until your cough improves, so make sure you talk to your doctor.

Starting a New Medication
A new medication for you today. Specialty medications are different from regular prescriptions, as you may not pick them up from your local pharmacy. Specialty medications acquisition require more steps than a regular prescription. The process is as follows:

  • The prescription is filled out on a form called a Referral. The physician will sign the form and it gets faxed to the manufacturers’ “Hub”. You may be asked to sign the form, as well.
  • Once the Hub receives the referral, they will verify your benefits with your current insurance. This helps them know which Specialty Pharmacy is in network with your insurance. The Hub will fax our office a Prior Authorization for the medication. Every Specialty Medication requires a Prior Authorization.
  • Prior Authorization is submitted to your insurance and they will review to see if it meets their criteria for approval. The process can take up to a couple of weeks depending on your insurance. If for some reason the insurance decides not to approve your medication, we will look to see why they made this decision and try to appeal this decision.
  • It is possible that your insurance will require a copay. In the case the copay is significant and you cannot afford the amount, you can ask special foundations for copay assistance. Non-Medicare patients can directly apply for assistance from the drug company manufacturing the drug. You will find more information in the Financial Assistance tab of this web page. Your physician’s office can also guide you in this matter. In spite of sometimes a hefty copay, through a variety of channels, patients usually are able to afford these specialty drugs- it does take some work by you to apply. You may receive phone calls during this time from the hub, the pharmacy, the drug company or assistance foundations to verify your income and assets. Please cooperate with them, they just want to help!
  • Once the medication is approved, the Specialty Pharmacy will be ready to ship it to you. You will receive a phone call from the Hub and/or from the Specialty Pharmacy. These will likely be 1-800 numbers. You have to answer the phone in order for them to be able to ship your medication to you. Please call them back. The medication will be mailed to your home address. Some medications require that a nurse from the Specialty Pharmacy visit you while you are taking the medication, your clinician will discuss this in detail if it applies to you.
  • You should work with all members of your Care Team during this process. This includes your physician, office nurse, Specialty Pharmacy staff (Pharmacist and Nurse).
Financial Support
United Therapeutics Financial Assistance

  • The Program is valid only for patients with commercial (also known as private) insurance who are taking the medication for an FDA approved indication
  • Patients using Medicare, Medicaid, or any other state or federal government program to pay for their medications are not eligible

Non-profit charitable assistance funds:

We maintain an updated list and verify if funding is available on a weekly basis.

For Medicare and Medicaid patients, the following foundations may be able to assist with copay support. It may take some work by you to apply. Your physician’s office, the Hub or specialty pharmacy contacts may help you through this. (See Starting a New Medication Tab)

Click here to see foundations.

Patient Support
Pulmonary Arterial Hypertension is a serious condition. The medications designed to fight the disease typically show benefit slowly, over months, with most needing 4 to 6 months for maximum effect. The adverse effects (Side-effects) of these medications, however happen upfront. Your body typically will get used to them either with time, or with additional natural remedy or drugs. This may also take 2 to 3 months. It is necessary that you have patience, and talk to your doctor or nurses about dealing with them. Sometimes slowing the planned increase or cutting down on medication for a while will allow your body to adjust. Discuss matters with your doctors’ office before taking action of your own. Patience is a virtue!
Useful Downloads From Tyvaso.com

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