Delay PAH progression to stay ahead
How can UPTRAVI help?
UPTRAVI® (selexipag) is a prescription medicine for PAH (WHO Group 1). It is used to treat the high blood pressure in the arteries of your lungs. Since PAH is a progressive disease, it can get worse over time. The goal of treatment with UPTRAVI is to help delay (slow down) PAH progression to stay ahead.
UPTRAVI reduced PAH progression by 40%
UPTRAVI® (selexipag) helps you stay ahead of your disease by reducing PAH-related hospitalizations and other PAH disease progression events.
- 27.0% of patients treated with UPTRAVI experienced a PAH disease progression event vs 41.6% of patients on placebo (a sugar pill)
In a clinical study of UPTRAVI, PAH disease progression was defined as a serious event, such as hospitalization for PAH; the need to start injectable PAH medications or chronic oxygen therapy; lung transplantation; a decline in 6-minute walk distance (6MWD) combined with worsening of functional class (FC) or need for additional PAH therapy; or death.
UPTRAVI reduced hospitalizations for PAH
This benefit was shown in a clinical trial that compared patients taking UPTRAVI® (selexipag) with those taking a placebo. Patients took UPTRAVI for an average of 1.4 years.
Patients taking UPTRAVI were able to walk farther than patients taking a placebo
At 6 months, in a clinical trial, UPTRAVI helped patients walk an average of 12 meters (about 39 feet) more than patients taking placebo, as measured by the 6-minute walk distance (6MWD).
Uptravi Side Effects
|Side Effect Severity||Mild||Moderate||Severe|
|Less Likely (1-10%)||
Decreased Appetite (6%)
You need to be prepared to work through the likely adverse effects. It would be advisable for patients to get prescriptions or guidance to deal with diarrhea, nausea and headache.
- Headache is treated with Tylenol (Acetaminophen).
- Taking Uptravi with food and the right diet will help avoid nausea and diarrhea. Please see section bellow on managing your diet.
It that is not enough:
- Diarrhea is typically treated with Imodium (Loperamide)- Purchase some before you start the medication to be prepared.
- Nausea is treated first with Zofran (ondansetron).
YOU WILL NOT NEED TO SUFFER SIDE EFFECTS FOR LONG! YOU WILL ALWAYS HAVE THE OPTION TO GO BACK TO A LOWER DOSE WHERE YOU WERE MORE CONFORTABLE. UPTRAVI WILL STILL WORK!
Please talk to your provider about preparing for adverse effects.
What to do if you miss a dose of UPTRAVI:
If you miss a dose of UPTRAVI, take it as soon as you remember. If your next scheduled dose is due within 6 hours, skip the missed dose. Take the next dose at your regular time
If you miss 3 or more days of UPTRAVI, call your healthcare provider to see if you need to change your dose
If you take too much UPTRAVI, call your healthcare provider or go to the nearest hospital emergency room right away
It is important to tell your healthcare provider if you have any form of liver disease as your healthcare provider may need to adjust your dose of UPTRAVI
Starting a New Medication
Pulmonary Arterial Hypertension is a serious condition. The medications designed to fight the disease typically show benefit slowly, over months, with most needing 4 to 6 months for maximum effect. The adverse effects (Side-effects) of these medications, however happen upfront. Your body typically will get used to them either with time, or with additional natural remedy or drugs. This may also take 2 to 3 months. It is necessary that you have patience, and talk to your doctor or nurses about dealing with them. Sometimes slowing the planned increase or cutting down on medication for a while will allow your body to adjust. Discuss matters with your doctors’ office before taking action of your own. Patience is a virtue!