Veletri® (Epoprostenol)
What is VELETRI?
VELETRI is a prescription medicine that is given intravenously (in a vein). It is used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH) (WHO Group 1), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. VELETRI may improve your ability to exercise as measured by how far you can walk in 6 minutes (6-minute walk test).
Studies showing VELETRI is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors or connective tissue disease.
Understanding Your PAH Treatment
In pulmonary arterial hypertension (PAH), your body does not have enough of certain substances called prostacyclin and nitric oxide. At the same time, your body may have too much of a substance called endothelin. This lack of balance can cause your blood vessels to become narrow, leading to PAH.
The active ingredient of VELETRI® (epoprostenol) for Injection is epoprostenol, which is a prostacyclin. VELETRI adds back the prostacyclin your body is missing. Epoprostenol is a proven therapy with the goal of opening up, or dilating, the blood vessels in the lungs. Once the blood vessels are open, oxygen-rich blood can flow more easily.
A pulmonary arterial hypertension (PAH) medication such as VELETRI has a very short half-life (the time it takes for half of the medication to be broken down and eliminated from the body). VELETRI has a half-life of approximately 6 minutes.1 Because of this, VELETRI cannot be given as a pill that can be swallowed. Instead, it must be continuously delivered intravenously (through a vein) through an I.V. line. This line is connected to a catheter (a very thin tube) that is placed into your heart.
You will need a surgical procedure done with local anesthesia so that the catheter can be placed into a large vein near your heart. The other end of the catheter is attached to a small, portable pump that holds the medication. You must carry or wear the pump and keep it on at all times.
The treatment of pulmonary arterial hypertension with I.V. epoprostenol, including VELETRI, can seem complicated and frightening at first. Over time for many people, it becomes more routine and easier to manage. When you begin your treatment with VELETRI, your healthcare professional will get you started by guiding you step by step through how to prepare, use, and store your medication; how to care for your catheter; and what to do if your pump stops working.
Importance of Taking VELETRI
It is very important to follow your healthcare professional’s instructions carefully regarding how to take VELETRI and how long to take it. Do not stop taking VELETRI for any reason, or lower the dose, unless your healthcare professional tells you to do so. Your healthcare professional can help you make taking VELETRI part of your daily routine.
Veletri Side Effects
Side Effect Severity | Mild | Moderate | Severe | ||
Likely (>10%) |
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Less Likely (1-10%) |
Abdominal Pain (5%) Musculoskeletal Pain (3%) |
Dizziness (8%) Slow Heart Rate (5%) |
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Rare (<1%) |
You need to be prepared to work through the likely adverse effects. It would be advisable for patients to get prescriptions or guidance to deal with Diarrhea, Nausea and headache.
Headache is treated with Tylenol (Acetaminophen).
Diarrhea is typically treated with Imodium (Loperamide)-Purchase some before you start the medication to be prepared.
Nausea is treated first with Zofran (ondansetron).
Please talk to your provider about preparing for adverse effects.
Starting a New Medication
A new medication for you today. Specialty medications are different from regular prescriptions, as you may not pick them up from your local pharmacy. Specialty medications acquisition require more steps than a regular prescription. The process is as follows:
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Prescription
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Insurance verification
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First treatment
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Delivery of medicine
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Refills
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Remember, the call from your specialty pharmacy may come from a phone number that you don’t know. If you miss the call, it’s important that you call back.
Financial Support
Please Refer to Financial Support Page at MedEdCenter
If you have insurance coverage when your healthcare provider first prescribes VELETRI, your healthcare team will submit your information to have your insurance plan pay for your prescription. Sometimes, your insurance plan needs additional information. Alternatively, if you do not have insurance but need assistance to meet out-of-pocket costs, there may be financial assistance options available. In both cases, an Actelion Pathways® Case Manager can help with the process.
Connecting with financial assistance programs
There are two programs that can help you pay for VELETRI. For information on these programs, contact an Actelion Pathways® Case Manager at 1-866-ACTELION (1-866-228-3546), Mon-Fri, 8 AM-8 PM ET.
Government Insured
If you receive your medication through Medicare or other government-funded plans, you may be eligible for the following:
Independent Foundations:
There may be support available from independent third-party patient support foundations. An Actelion Pathways Case Manager can provide general information about resources.
Uninsured or Underinsured
If you are uninsured or you have insurance but are unable to afford the out-of-pocket costs, you may be eligible for the following programs:
Patient Assistance Program (PAP):
A yearly program that helps eligible patients receive medicine at no cost. Contact an Actelion Pathways Case Manager to learn more and to ensure the PAP program is the best option for you before applying.
Patient Support
Expectations
Pulmonary Arterial Hypertension is a serious condition. The medications designed to fight the disease typically show benefit slowly, over months, with most needing 4 to 6 months for maximum effect. The adverse effects (Side-effects) of these medications, however happen upfront. Your body typically will get used to them either with time, or with additional natural remedy or drugs. This may also take 2 to 3 months. It is necessary that you have patience, and talk to your doctor or nurses about dealing with them. Sometimes slowing the planned increase or cutting down on medication for a while will allow your body to adjust. Discuss matters with your doctors’ office before taking action of your own. Patience is a virtue!
Useful Downloads
Life with Pulmonary Hypertension
Fluid Management
Emergency Situations

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